Mary Ann Turley, DO, CMIO, and Kristin Gillen, RN, DNP, CNML, CNIO, HonorHealth. The dyad relationship between the CMIO and CNIO at HonorHealth was specifically designed to help the organization achieve its strategic vision through Clinical Transformation. Dr. Mary Ann Turley, as CMIO and Kris Gillen, as CNIO are both operational by background and serve as content experts in clinical informatics as well as liaisons between IT and operations. Developing excellent communication pathways between the CNIO and CMIO was imperative during this large enterprise-wide EMR go-live, both for their mutual success as well as for their “customers” in both the IT departments and the hospital clinical areas. Dr. Turley and Kris discuss how they navigated through challenging cultural and standard of care differences among the system’s hospitals – two of whom were already live on Epic and three of whom were not – to build an entirely new instance of Epic that went live on all five campuses the same day. They will also share their perspectives on the leadership, expertise, and relationship-building skills that were critical during this clinical transformation process.